3,041 research outputs found
Promoting Music Therapy Referrals for Neurodivergent Children
Music therapy is perhaps an underutilized, underfunded, and undervalued part of the tool kit available to physicians, parents and children with ASD and other developmental disabilities within Clinton County. There are opportunities to increase referrals for music therapy for children receiving care at the CVPH Family Medicine Center and within the county.https://scholarworks.uvm.edu/fmclerk/2020/thumbnail.jp
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Reported light in the sleep environment: enhancement of the sleep diary.
BackgroundLight is the primary synchronizing cue for the circadian timing system, capable of exerting robust physiological effects, even with very dim and/or brief photic exposure. Mammals, including humans, are particularly susceptible to light at night. As such, measures of light in the sleeping environment are critical for evaluating sleep health. Sleep diaries provide inexpensive measures of sleep, but do not typically include light information.MethodsFour questions probing visual perception of light in the bedtime and waking environments were added to the Consensus Sleep Diary for Morning administration. As part of a lighting intervention study, 18 hospital Labor and Delivery Department personnel completed the sleep diary for 1 week in each of two experimental conditions while wearing Actiwatch devices equipped with photosensors. Diary responses were evaluated against photosensor values from the beginning and end of each rest interval (n=194 rest intervals), as well as against sleep measures, utilizing linear mixed models.ResultsResponses to light questions were related to actual light measures at bedtime, controlling for shift type and experimental condition. In addition, subjective light information at bedtime and waking was related to both objective and subjective sleep parameters, with data generally indicating poorer sleep with light in the sleeping environment.ConclusionQuestions addressing perception of light in the sleeping environment may provide a crude yet affordable metric of relative photic intensity. Further, as responses relate to sleep outcomes, subjective light information may yield valuable insights regarding mechanisms and outcomes of clinical significance in sleep and circadian research
High-fidelity state detection and tomography of a single ion Zeeman qubit
We demonstrate high-fidelity Zeeman qubit state detection in a single trapped
88 Sr+ ion. Qubit readout is performed by shelving one of the qubit states to a
metastable level using a narrow linewidth diode laser at 674 nm followed by
state-selective fluorescence detection. The average fidelity reached for the
readout of the qubit state is 0.9989(1). We then measure the fidelity of state
tomography, averaged over all possible single-qubit states, which is 0.9979(2).
We also fully characterize the detection process using quantum process
tomography. This readout fidelity is compatible with recent estimates of the
detection error-threshold required for fault-tolerant computation, whereas
high-fidelity state tomography opens the way for high-precision quantum process
tomography
Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue.
Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications. The high similarity of organoid-derived retinal tissue and transplantable human fetal retina provides an opportunity for evaluating and modeling retinal tissue replacement strategies in relevant animal models in the effort to develop a functional retinal patch to restore vision in patients with profound blindness caused by retinal degeneration. Because of the complexity of this very promising approach requiring specialized stem cell and grafting techniques, the tasks of retinal tissue derivation and transplantation are frequently split between geographically distant teams. Delivery of delicate and perishable neural tissue such as retina to the surgical sites requires a reliable shipping protocol and also controlled temperature conditions with damage-reporting mechanisms in place to prevent transplantation of tissue damaged in transit into expensive animal models. We have developed a robust overnight tissue shipping protocol providing reliable temperature control, live monitoring of the shipment conditions and physical location of the package, and damage reporting at the time of delivery. This allows for shipping of viable (transplantation-competent) hPSC-derived retinal tissue over large distances, thus enabling stem cell and surgical teams from different parts of the country to work together and maximize successful engraftment of organoid-derived retinal tissue. Although this protocol was developed for preclinical in vivo studies in animal models, it is potentially translatable for clinical transplantation in the future and will contribute to developing clinical protocols for restoring vision in patients with retinal degeneration
The cost and risk impacts of rerouting railroad shipments of hazardous materials
Cataloged from PDF version of article.Rail shipments of hazardous materials expose the population near the routes to the possibility of an accident resulting in a spill. Rail routes are
determined by economic concerns such as route length and the revenue generated for the originating carrier. In this paper we consider an alternate
routing strategy that takes accident risks into account. We employ a model to quantify rail transport risk and then use a weighted combination of
cost and risk and generate alternate routes. In some cases the alternate routes achieve significantly lower risk values than the practical routes at a
small incremental cost. While there are generally fewer rerouting alternatives for rail than for road transport, considering the possible consequences
of a train derailment we argue that risk should be taken into account when selecting rail routes and that the cost–risk tradeoffs should be evaluated.
© 2007 Elsevier Ltd. All rights reserved
A core genetic module : the Mixed Feedback Loop
The so-called Mixed Feedback Loop (MFL) is a small two-gene network where
protein A regulates the transcription of protein B and the two proteins form a
heterodimer. It has been found to be statistically over-represented in
statistical analyses of gene and protein interaction databases and to lie at
the core of several computer-generated genetic networks. Here, we propose and
mathematically study a model of the MFL and show that, by itself, it can serve
both as a bistable switch and as a clock (an oscillator) depending on kinetic
parameters. The MFL phase diagram as well as a detailed description of the
nonlinear oscillation regime are presented and some biological examples are
discussed. The results emphasize the role of protein interactions in the
function of genetic modules and the usefulness of modelling RNA dynamics
explicitly.Comment: To be published in Physical Review
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